Ingredients: Serenoa Repens (Serenoa repens Small.), fat-soluble extract titrated to 90%-95% in fatty acids, Food Gelatin, Glycerin, Water.
Serenoa repens (Serenoa repens Small.), fat-soluble extract titrated to 90-95% in fatty acids
Serenoa Repens (Saw Palmetto, Sabal serrulata, Dwarf palm) is a small broad-leaved plant with dark red berries native to the United States South Atlantic Coast (specifically Florida), as well as Southern Europe and North Africa.
The berry contains one main active ingredient, beta-sitosterol, as well as other sterols, free fatty acids, carotenoids, essential oils and polysaccharides.
Natives used the berries to treat urologic dysfunction, prostate inflammation, erectile dysfunction and testicular atrophy.
As early as the late 20th century, the extract was included in the official American pharmacopoeia. However, it was only recently that its efficacy in treating benign prostate hyperplasia was acknowledged by a series of controlled clinical trials conducted on approximately 3,000 patients.
Its mechanism of action is not known: it may depend on the combination of an antagonistic effect on sex hormones, anti-inflammatory action and alteration of cholesterol metabolism.
In the United States, the National Institute of Health has shown its interest in the small palm. However, the literature published so far is inadequate, especially with regard to the duration of trials and the variability of research protocols.
The lipophilic extract (90-95 % of fatty acids and sterols) of the berries of Serenoa repens has long been used as an adjuvant in the treatment of benign prostatic hyperplasia stage I and II and the symptoms associated with it.
Taken orally, it has been shown to have clear anti-androgenic effects, inhibiting the enzyme 5-alpha-reductase.
In short, the efficacy of Serenoa repens is given by the synergy of different mechanisms of action:
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Inhibition of 5-alpha-reductase, an enzyme involved in converting testosterone to dihydrotestosterone (DHT)
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Selective local antagonism of the link between dihydrotestosterone and androgen receptors.
Hence it can be considered a sound alternative to the synthetic drug finasteride in the treatment of benign prostatic hypertrophy (BPH) and in the treatment of male androgenetic alopecia (AGA).
Quantities per maximum recommended daily dose (1 softgel)
Serenoa Repens (Serenoa repens Small.)
Fat-soluble extract titrated to 90-95% in fatty acids
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320 mg
288 - 304 mg
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Recommended intake: 1 softgel daily, with plenty of water.
The softgel can be taken at any time of the day, with or between meals.